Isopropanol → 2-((2R)-2-hydroxy-3-((4-(3-oxomorpholin-4-yl)phenyl)amino)propyl)-1H-isoindole-1,3(2H)-dione

HRID 1054144

反応式

HRID 1054144 の反応式
C(O)(C)C.[NH2:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][C:13]2=[O:18])=[CH:8][CH:7]=1.[O:19]1[CH2:21][C@@H:20]1[CH2:22][N:23]1[C:31](=[O:32])[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]1=[O:33]>O>[OH:19][C@H:20]([CH2:21][NH:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][C:13]2=[O:18])=[CH:10][CH:11]=1)[CH2:22][N:23]1[C:24](=[O:33])[C:25]2[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:31]1=[O:32]

参加物

5

反応物 3

HCID 3776IsopropanolHCID 719412(S)-(+)-N-(2,3-Epoxypropyl)phthalimideHCID 111948544-(4-Aminophenyl)morpholin-3-one

生成物 1

HCID 115167582-((2R)-2-hydroxy-3-((4-(3-oxomorpholin-4-yl)phenyl)amino)propyl)-1H-isoindole-1,3(2H)-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
27.5 °C

実験手順

In a four neck round bottom flask charged Isopropyl alcohol (135 ml), 4-(4-aminophenyl) morpholin-3-one (10 g), 2-[(2s)-oxiran-2yl methyl]-1H-isoindole-1,3(2H)dione ((11.6 g) and water (15 ml) at 25 to 30° C. Slowly heated the reaction mixture to reflux and maintained for 24 h at reflux temperature. Reaction mass is cooled to 25 to 30° C. after completion of the reaction. Reaction mass then maintained at 25 to 30° C. for 30 minutes. Finally obtained solid is filtered off and washed by isopropyl alcohol (25 ml)

後処理

  1. temperatureSlowly heated the reaction mixture
  2. temperatureto reflux
  3. temperaturemaintained for 24 h
  4. temperatureat reflux temperature
  5. customReaction mass
  6. customafter completion of the reaction
  7. customReaction mass
  8. temperaturethen maintained at 25 to 30° C. for 30 minutes
  9. filtrationFinally obtained solid is filtered off
  10. washwashed by isopropyl alcohol (25 ml)

出典と根拠

ORDレコード
ord-9d91ac34bb444a548330beea6e7bc495
出典データセット
uspto-grants-2016_07
特許番号
US09394292B2

関連ノート

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