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Potassium Iodide → (R)-2-Phenyl-2-pyrrolidin-1-yl-ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | 1,4-Dibromobutane | HCID 8056 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | (R)-beta-aminophenethyl alcohol | HCID 2724025 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | (R)-2-Phenyl-2-pyrrolidin-1-yl-ethanol | HCID 11030628 | — |
反応手順
To a solution of (R)-2-amino-2-phenyl-ethanol (0.5 g, 3.64 mmol) in 2-propanol (40 mL) were added sodium carbonate (1 g, 9.48 mmol), 1,4-dibromobutane (0.57 mL, 4.74 mmol) and potassium iodide (catalytic) in succession, and the mixture was refluxed overnight. After filtration, the solvent was removed under reduced pressure and the crude was used without further purification (0.53 g, 76%). LCMS method: 2, RT: 2.27 min; MI: 191-193 [M+1].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09394301B2 |
| 出典データセット | uspto-grants-2016_07 |
| ORD ID | ord-36f84046dbc34129b9f9824aea9f2e4a |
| 出典メモ | uspto-grants-2016_07 |