Hydrochloride methanol → N-(4-vinyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

HRID 10545ノート

反応式

HRID 10545 の反応式
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([CH:26]=[CH2:27])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:28].CO>>[ClH:28].[CH:26]([C:18]1[C:17]2[C:22](=[CH:23][CH:24]=[CH:25][C:16]=2[NH:15][CH:12]2[CH2:13][CH2:14][CH:9]([NH2:8])[CH2:10][CH2:11]2)[CH:21]=[N:20][CH:19]=1)=[CH2:27]

参加物

3

反応物 2

HCID 21893726Hydrochloride methanolHCID 21979768N-(tert-butoxycarbonyl)-N'-(4-vinyl-5-isoquinolyl)-1,4-cyclohexanediamine

生成物 1

HCID 21979839N-(4-vinyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

実験手順

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 85 (85.5 mg) and 10% hydrogen chloride/methanol solution (2 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (52.3 mg).

後処理

  1. custom(50° C., 2 hours)
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-46e100f7ec384b35afcd5adf91303a2d
出典データセット
uspto-grants-2006_08
特許番号
US07094789B2

反応ノート

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