Hydrochloric Acid → 2-(4-Bromophenyl)pyrrolidine hydrochloride

HRID 1054769

反応式

HRID 1054769 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2C(OC(C)(C)C)=O)=[CH:4][CH:3]=1.[ClH:20]>CO>[ClH:20].[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 53407516tert-Butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate

生成物 1

HCID 534075152-(4-Bromophenyl)pyrrolidine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

The suspension of tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate (1.2 g, 3.7 mmol) in anhydrous methanol (10 mL) was added hydrogen chloride in methanol (20 mL, 4.0 M in MeOH) under nitrogen. The reaction was stirred at room temperature for 1.5 hours. The mixture was concentrated to afford the title compound (0.99 g, quantitative yield) which was used without purification in the next step.

後処理

  1. concentrationThe mixture was concentrated

出典と根拠

ORDレコード
ord-795ccc6c6ea94043b842f7f0fb007d62
出典データセット
uspto-grants-2016_07
特許番号
US09394285B2

関連ノート

読み込み中…