Pyruvic Acid → 7-Chloro-3-methylquinoxalin-2(1h)-one

HRID 1055031ノート

反応式

HRID 1055031 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.O=[C:11]([CH3:15])[C:12](O)=[O:13]>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[NH:8][C:12](=[O:13])[C:11]([CH3:15])=[N:9]2.[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([N:8]=[C:11]([CH3:15])[C:12](=[O:13])[NH:9]2)=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 1060Pyruvic AcidHCID 72634-Chloro-1,2-diaminobenzene

生成物 2

HCID 2581487-Chloro-3-methylquinoxalin-2(1h)-one収率 148.1%HCID 11636992HCID 11636992、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

4-chlorobenzene-1,2-diamine (5 g, 35.1 mmol, Eq: 1.00) was stirred in water (50 ml) at room temperature. 2-Oxopropanoic acid (3.09 g, 2.44 ml, 35.1 mmol, Eq: 1.00) in water (20 ml) was added drop wise. The dark mixture was stirred at room temperature for 30 min. The precipitate was filtered off and washed with water and dried under high vacuum to give 6-chloro-3-methyl-1H-quinoxalin-2-one with 7-chloro-3-methyl-1H-quinoxalin-2-one (5.06 g, 37.1%) as brown solid. MS: m/z=195.03 (M+H+)

後処理

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-0fca87ee4d614167b080439c3007499c
出典データセット
uspto-grants-2016_07
特許番号
US09394311B2

反応ノート

読み込み中…