Water → HCID 90037382、化合物

HRID 1055412ノート

反応式

HRID 1055412 の反応式
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:11]#[N:12].F[C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[C:16]#[N:17].C([O-])([O-])=O.[Cs+].[Cs+].O>CN(C=O)C>[C:16]([C:15]1[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=1[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2]([CH3:1])=[C:3]1[C:11]#[N:12])#[N:17]

参加物

6

反応物 4

HCID 962WaterHCID 10796Cesium carbonateHCID 678552-FluorobenzonitrileHCID 5933713-Methyl-1H-indole-2-carbonitrile

生成物 1

HCID 90037382HCID 90037382、化合物収率 94.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

A mixture of 3-methyl-1H-indole-2-carbonitrile (500 mg, 3.2 mmol), 2-fluorobenzonitrile (388 mg, 3.2 mmol) and Cs2CO3 (1.05 g, 3.2 mmol) in DMF (10 mL) was heated at 60° C. overnight. The mixture was poured into H2O and a precipitate formed. The solid was collected by filtration, washed with H2O and hexane, and dried under vacuum to give 1-(2-cyanophenyl)-3-methyl-1H-indole-2-carbonitrile (780 mg, 94.6%) as an off white solid that was used without purification.

後処理

  1. customa precipitate formed
  2. filtrationThe solid was collected by filtration
  3. washwashed with H2O and hexane
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-64051bb5bd894dc69ab7f1c804b95350
出典データセット
uspto-grants-2016_07
特許番号
US09394263B2

反応ノート

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