2-Fluorobenzonitrile → 2-(3-(Bromomethyl)-6-fluoro-1H-indazol-1-yl)benzonitrile
反応式
[Br:1][CH2:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([C:12]2[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=2[C:14]#[N:15])[N:4]=1.[F:20]C1C=C2C(C(C)=NN2)=CC=1.FC1C=CC=CC=1C#N>O>[Br:1][CH2:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([F:20])=[CH:9][CH:10]=2)[N:5]([C:12]2[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=2[C:14]#[N:15])[N:4]=1参加物
5
実験手順
In a similar manner to that described for the preparation of 2-(3-(bromomethyl)-1H-indazol-1-yl)benzonitrile except in Step 1 the mixture was diluted with H2O and in Step 2 the mixture was heated at reflux overnight, 6-fluoro-3-methyl-1H-indazole (2 g, 13.3 mmol) and 2-fluorobenzonitrile (1.73 mL, 16 mmol) were converted to the title compound (800 mg, 61%) as an off white solid.