Uracil → 5-Iodouracil

HRID 1055624ノート

反応式

HRID 1055624 の反応式
N1C=CC(=O)NC1=O.[I:9][C:10]1[C:11](=[O:21])[NH:12][C:13](=[O:20])[N:14](CC(O)=O)[CH:15]=1.C(C(N)CNCC(OCC)=O)(OC(C)(C)C)=O>>[I:9][C:10]1[C:11](=[O:21])[NH:12][C:13](=[O:20])[NH:14][CH:15]=1

参加物

4

反応物 3

HCID 1174UracilHCID 1361763(5-Iodo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetic acidHCID 57253309HCID 57253309、化合物

生成物 1

HCID 696725-Iodouracil

実験手順

The PNA trimer can be synthesized manually or in an automated peptide synthesizer. The synthesis of universal base PNA monomer has been reported in the literature129,130 The modified uracil PNA monomer may be synthesized starting from 5-iodouracil-1-acetic acid.131 The starting material reacts with ethyl N-[2-Boc-aminoethyl]glycinate, providing a 5-iodouracil PNA monomer that can be converted into the desired product through the Sonogashira coupling132 with 3-benzoylthio-1-propyne followed by treating with di-tbutyl-1-(tbutylthio)hydrazine-1,2-dicarboxylate.34

後処理

  1. customThe synthesis of universal base PNA monomer
  2. custommay be synthesized

出典と根拠

ORDレコード
ord-a69cfa82f3f64dcfbab481e5f1e4a4f6
出典データセット
uspto-grants-2016_07
特許番号
US09395352B2

反応ノート

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