1-(2,2-Diethoxyethyl)-1'-(4-methoxybenzyl)-1H,1'H-3,4'-bipyrazol-5-amine → HCID 178490761、化合物

HRID 1055633

反応式

HRID 1055633 の反応式
C(O[CH:4](OCC)[CH2:5][N:6]1[C:10]([NH2:11])=[CH:9][C:8]([C:12]2[CH:13]=[N:14][N:15]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[CH:16]=2)=[N:7]1)C>C(O)C.S(=O)(=O)(O)O>[CH3:25][O:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:15]2[CH:16]=[C:12]([C:8]3[CH:9]=[C:10]4[NH:11][CH:4]=[CH:5][N:6]4[N:7]=3)[CH:13]=[N:14]2)=[CH:19][CH:20]=1

参加物

4

反応物 1

HCID 866909601-(2,2-Diethoxyethyl)-1'-(4-methoxybenzyl)-1H,1'H-3,4'-bipyrazol-5-amine

生成物 1

HCID 178490761HCID 178490761、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 1118Sulfuric Acid溶媒

実験手順

In a microwave oven (Biotage Initiator, with Dynamic Field Tuning), 155 mg (0.40 mmol) of the compound of Example 2A in 0.4 ml of ethanol and 0.2 ml of 2 M sulphuric acid were heated at 120° C. for 15 min. The reaction was then purified directly by preparative HPLC (Method 11). The product fractions were concentrated and the residue was dried under high vacuum. This gave 54 mg (46% of theory) of the title compound.

後処理

  1. customThe reaction was then purified directly by preparative HPLC (Method 11)
  2. concentrationThe product fractions were concentrated
  3. customthe residue was dried under high vacuum

出典と根拠

ORDレコード
ord-f72c1db23d20489c994c6c8744136b83
出典データセット
uspto-grants-2016_07
特許番号
US09394309B2

関連ノート

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