3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate → 3-tert-Butyl-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pyrrolidin-1-ylmethyl)benzamide

HRID 1055670ノート

反応式

HRID 1055670 の反応式
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[CH:37]=[CH:36][C:13]([CH2:14][N:15]2[CH:19]=[C:18]([C:20]3[CH:21]=[C:22]4[N:27]([C:28]5[CH:29]=[C:30]([CH:32]=[CH:33][C:34]=5[CH3:35])[NH2:31])[CH:26]=[CH:25][N:23]4[N:24]=3)[CH:17]=[N:16]2)=[CH:12][CH:11]=1.FC(F)(F)C(O)=O.[C:45]([C:49]1[CH:50]=[C:51]([CH:55]=[C:56]([CH2:58][N:59]2[CH2:63][CH2:62][CH2:61][CH2:60]2)[CH:57]=1)[C:52](O)=[O:53])([CH3:48])([CH3:47])[CH3:46]>>[C:45]([C:49]1[CH:50]=[C:51]([CH:55]=[C:56]([CH2:58][N:59]2[CH2:60][CH2:61][CH2:62][CH2:63]2)[CH:57]=1)[C:52]([NH:31][C:30]1[CH:32]=[CH:33][C:34]([CH3:35])=[C:28]([N:27]2[C:22]3[N:23]([N:24]=[C:20]([C:18]4[CH:17]=[N:16][N:15]([CH2:14][C:13]5[CH:12]=[CH:11][C:10]([O:9][CH3:8])=[CH:37][CH:36]=5)[CH:19]=4)[CH:21]=3)[CH:25]=[CH:26]2)[CH:29]=1)=[O:53])([CH3:48])([CH3:46])[CH3:47]

参加物

3

反応物 2

HCID 896998093-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetateHCID 897000263-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline trifluoroacetate

生成物 1

HCID 896996523-tert-Butyl-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pyrrolidin-1-ylmethyl)benzamide

実験手順

70 mg (0.14 mmol) of the compound of Example 8A and 51 mg (0.14 mmol) of the compound of Example 22A were reacted analogously to the procedure of Example 48A. This gave 83 mg (88% pure, 83% of theory) of the title compound.

出典と根拠

ORDレコード
ord-eb0c4668826647efa5e0f58036f912f5
出典データセット
uspto-grants-2016_07
特許番号
US09394309B2

反応ノート

読み込み中…