3-(4-Methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid trifluoroacetate → N-(3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-3-(4-methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

HRID 1055671ノート

反応式

HRID 1055671 の反応式
[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=5[CH3:28])[NH2:24])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:5][CH:4]=1.FC(F)(F)C(O)=O.[CH3:39][N:40]1[CH2:45][CH2:44][N:43]([C:46]2[CH:47]=[C:48]([CH:52]=[C:53]([S:55]([F:60])([F:59])([F:58])([F:57])[F:56])[CH:54]=2)[C:49](O)=[O:50])[CH2:42][CH2:41]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([NH:24][C:49](=[O:50])[C:48]6[CH:52]=[C:53]([S:55]([F:60])([F:56])([F:57])([F:58])[F:59])[CH:54]=[C:46]([N:43]7[CH2:42][CH2:41][N:40]([CH3:39])[CH2:45][CH2:44]7)[CH:47]=6)[CH:25]=[CH:26][C:27]=5[CH3:28])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:30][CH:31]=1

参加物

3

反応物 2

HCID 896995603-(4-Methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid trifluoroacetateHCID 896998613-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline

生成物 1

HCID 89699504N-(3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-3-(4-methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

実験手順

70 mg (0.17 mmol) of the compound of Example 9A and 78 mg (0.17 mmol) of the compound of Example 17A were reacted and worked up analogously to the procedure of Example 48A. This gave 125 mg (95% of theory) of the title compound.

出典と根拠

ORDレコード
ord-f7b7093cbb9b46f4bc8e89567ca48434
出典データセット
uspto-grants-2016_07
特許番号
US09394309B2

反応ノート

読み込み中…