3-Cyano-5-(pentafluoro-lambda6-sulphanyl)benzoic acid → 3-Cyano-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

HRID 1055673ノート

反応式

HRID 1055673 の反応式
[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=5[CH3:28])[NH2:24])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:5][CH:4]=1.[C:32]([C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([S:43]([F:48])([F:47])([F:46])([F:45])[F:44])[CH:42]=1)[C:37](O)=[O:38])#[N:33]>>[C:32]([C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([S:43]([F:47])([F:48])([F:44])([F:45])[F:46])[CH:42]=1)[C:37]([NH:24][C:23]1[CH:25]=[CH:26][C:27]([CH3:28])=[C:21]([N:20]2[C:15]3[N:16]([N:17]=[C:13]([C:11]4[CH:10]=[N:9][N:8]([CH2:7][C:6]5[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:31][CH:30]=5)[CH:12]=4)[CH:14]=3)[C:18]([CH3:29])=[CH:19]2)[CH:22]=1)=[O:38])#[N:33]

参加物

3

反応物 2

HCID 896998123-Cyano-5-(pentafluoro-lambda6-sulphanyl)benzoic acidHCID 896998613-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline

生成物 1

HCID 896997643-Cyano-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

実験手順

100 mg (0.24 mmol) of the compound of Example 9A and 66 mg (0.24 mmol) of the compound of Example 23A were reacted and worked up analogously to the procedure of Example 48A. This gave 153 mg (77% pure, 73% of theory) of the title compound.

出典と根拠

ORDレコード
ord-78138ac84ec34b288cef3e9cb8e34952
出典データセット
uspto-grants-2016_07
特許番号
US09394309B2

反応ノート

読み込み中…