3-Cyano-5-(pentafluoro-lambda6-sulphanyl)benzoic acid → 3-Cyano-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide
反応式
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=5[CH3:28])[NH2:24])[CH:19]=[CH:18][N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:5][CH:4]=1.[C:31]([C:33]1[CH:34]=[C:35]([CH:39]=[C:40]([S:42]([F:47])([F:46])([F:45])([F:44])[F:43])[CH:41]=1)[C:36](O)=[O:37])#[N:32]>>[C:31]([C:33]1[CH:34]=[C:35]([CH:39]=[C:40]([S:42]([F:46])([F:47])([F:43])([F:44])[F:45])[CH:41]=1)[C:36]([NH:24][C:23]1[CH:25]=[CH:26][C:27]([CH3:28])=[C:21]([N:20]2[C:15]3[N:16]([N:17]=[C:13]([C:11]4[CH:10]=[N:9][N:8]([CH2:7][C:6]5[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:30][CH:29]=5)[CH:12]=4)[CH:14]=3)[CH:18]=[CH:19]2)[CH:22]=1)=[O:37])#[N:32]参加物
3
反応物 2
生成物 1
実験手順
80 mg (0.16 mmol) of the compound of Example 60A and 66 mg (0.24 mmol) of the compound of Example 23A were reacted with one another analogously to Example 48A. In deviation from the work-up described therein, here, the mixture was separated directly into its components by preparative HPLC (Method 21). The product-containing fractions were concentrated under reduced pressure and the residue was dried under high vacuum. This gave 84 mg (64% of theory, 80% pure) of the title compound.
後処理
- customhere, the mixture was separated directly into its components by preparative HPLC (Method 21)
- concentrationThe product-containing fractions were concentrated under reduced pressure
- customthe residue was dried under high vacuum
出典と根拠
- ORDレコード
- ord-62509c420c4342d18528512d93d1e75c
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09394309B2
反応ノート
読み込み中…