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Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → N-{2,4-Dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(methoxymethyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

HRID 1055755
ノート
印刷プレビュー

反応式

HRID 1055755 の反応式
[CH3:1]N(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C[C:26]1[C:32]([N:33]2[C:40]3[N:36]([N:37]=[C:38]([C:41]4[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=4)[CH:39]=3)[CH:35]=[CH:34]2)=[C:31]([CH3:47])[CH:30]=[CH:29][C:27]=1[NH2:28].[CH3:48][O:49][CH2:50][C:51]1[CH:52]=[C:53]([CH:57]=[C:58]([S:60]([F:65])([F:64])([F:63])([F:62])[F:61])[CH:59]=1)[C:54](O)=[O:55]>CN(C=O)C.CO>[CH3:1][C:29]1[CH:30]=[C:31]([CH3:47])[C:32]([N:33]2[C:40]3[N:36]([N:37]=[C:38]([C:41]4[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=4)[CH:39]=3)[CH:35]=[CH:34]2)=[CH:26][C:27]=1[NH:28][C:54](=[O:55])[C:53]1[CH:57]=[C:58]([S:60]([F:65])([F:64])([F:63])([F:62])[F:61])[CH:59]=[C:51]([CH2:50][O:49][CH3:48])[CH:52]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 89699939HCID 89699939、化合物HCID 897000823-(Methoxymethyl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid

生成物 1

HCID 89699909N-{2,4-Dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(methoxymethyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6228Dimethylformamide溶媒

実験手順

75 mg (0.198 mmol) of HATU, 24 mg (0.198 mmol) of 4-N,N-dimethylaminopyridine (DMAP) and 50 mg (0.165 mmol) of the compound of Example 11A were added to a solution of 51 mg (0.173 mmol) of the compound of Example 74A in 1 ml of anhydrous DMF. The reaction mixture was stirred at RT for 1 h, then diluted with about 2 ml of methanol and subsequently directly separated into its components by preparative HPLC (Method 32). Evaporation of the product fractions and drying of the residue under high vacuum gave 60 mg (63% of theory) of the title compound.

後処理

  1. customsubsequently directly separated into its components by preparative HPLC (Method 32)
  2. customEvaporation of the product fractions
  3. customdrying of the residue under high vacuum

出典と根拠

ORDレコード
ord-eac742d9687f4defa024ff7f7a338c4f
出典データセット
uspto-grants-2016_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09394309B2

反応ノート

読み込み中…

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