Stannane, tributyl(1-ethoxyethenyl)- → 8-(1-Ethoxyvinyl)-2-phenylquinoline

HRID 1056055ノート

反応式

HRID 1056055 の反応式
Br[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:8]=[CH:7]2.C([Sn](CCCC)(CCCC)[C:23]([O:25][CH2:26][CH3:27])=[CH2:24])CCC>C1(C)C=CC=CC=1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH2:26]([O:25][C:23]([C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:8]=[CH:7]2)=[CH2:24])[CH3:27]

参加物

5

反応物 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 707004958-Bromo-2-phenylquinoline

生成物 1

HCID 897820818-(1-Ethoxyvinyl)-2-phenylquinoline

試薬・触媒・溶媒 2

HCID 178418476HCID 178418476、化合物触媒HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

In a sealed tube, to the suspension of 8-bromo-2-phenylquinoline (0.1 g, 0.352 mmol) in toluene (5 mL) was added PdCl2(PPh3)2 (0.012 g, 0.017 mmol) and tributyl (1-ethoxyvinyl)stannane (0.15 g, 0.422 mmol) under N2. The reaction was heated at 80° C. for 12 h, then cooled to RT. The solvent was removed and the crude material was used in the next step without further purification.

後処理

  1. temperaturecooled to RT
  2. customThe solvent was removed
  3. customthe crude material was used in the next step without further purification

出典と根拠

ORDレコード
ord-3b2faf61259145aea56ce4f3fa242058
出典データセット
uspto-grants-2016_07
特許番号
US09394297B2

反応ノート

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