関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyruvic Acid | HCID 1060 | — |
| 反応物 | 2-Chloropyridine-3,4-diamine | HCID 285736 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178432270 | HCID 178432270 | 65.7% |
反応手順
A mixture of 3,4-diamino-2-chloropyridine (2.1 g, 14.63 mmol) (Sigma Aldich) and pyruvic acid (1.22 mL, 17.55 mmol) (Acros, New Jersey) in MeOH (40 mL) in a sealed glass tube was heated at 50° C. for 2 h. The mixture was cooled to RT and the solvent was removed in vacuo. The residue was triturated with ether and the suspension was filtered to give 1.88 g of crude product. MS (ESI, pos. ion) m/z: 196.1 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09394297B2 |
|---|
| 出典データセット | uspto-grants-2016_07 |
|---|
| ORD ID | ord-5c3cc1e123fc447d8c33780bcb59abdc |
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| 出典メモ | uspto-grants-2016_07 |
|---|
