Hydrochloride methanol → HCID 178418896、化合物

HRID 10565

反応式

HRID 10565 の反応式
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([Br:26])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:27].CO>>[ClH:27].[Br:26][C:18]1[C:17]2[C:22](=[CH:23][CH:24]=[CH:25][C:16]=2[O:15][C@H:12]2[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]2)[CH:21]=[N:20][CH:19]=1

参加物

3

反応物 2

HCID 21893726Hydrochloride methanolHCID 178418932HCID 178418932、化合物

生成物 1

HCID 178418896HCID 178418896、化合物

実験手順

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 121 (49.4 mg) and 10% hydrogen chloride/methanol solution (2 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (0.5 ml) and diethyl ether (1.5 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (44.3 mg).

後処理

  1. custom(room temperature, 2 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (0.5 ml) and diethyl ether (1.5 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-4e85aeddbc554fecbb78e2baa0b93744
出典データセット
uspto-grants-2006_08
特許番号
US07094789B2

関連ノート

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