Dichloromethane → HCID 18629485、化合物

HRID 1056575ノート

反応式

HRID 1056575 の反応式
[C:1]([O:5][C:6]([NH:8][CH:9]([CH:13]([CH3:15])[CH3:14])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[CH2:21](Cl)[Cl:22]>O>[C:1]([O:5][C:6]([NH:8][CH:9]([CH:13]([CH3:15])[CH3:14])[C:10]([O:12][CH2:21][Cl:22])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 6344Dichloromethane2 回HCID 270655Boc-DL-valineHCID 516892Sodium Bicarbonate

生成物 1

HCID 18629485HCID 18629485、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The title compound was prepared according to the procedure as described in Example 17 Step 1 using 2-((tert-butoxycarbonyl)amino)-3-methylbutanoic acid (1 g, 4.6 mmol) in DCM (25 mL) and H2O (25 mL), NaHCO3 (1.55 g, 18.4 mmol), TBAHSO4 (156 mg, 0.46 mmol) and a solution of chloromethyl sulfochloridate (559 μL, 5.5 mmol) in DCM (5 mL). The title compound was obtained as colorless oil (877 mg, 71.8%). The title compound was characterized by 1H NMR as shown below:

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-2298ed8be94b4840b5a0d817f6208c1f
出典データセット
uspto-grants-2016_07
特許番号
US09399639B2

反応ノート

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