Dichloromethane → Chloromethyl 2-{[(tert-butoxy)carbonyl]amino}acetate

HRID 1056577ノート

反応式

HRID 1056577 の反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[CH2:18](Cl)[Cl:19]>O>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([O:12][CH2:18][Cl:19])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 6344Dichloromethane2 回HCID 78288N-(tert-butoxycarbonyl)glycineHCID 516892Sodium Bicarbonate

生成物 1

HCID 12968718Chloromethyl 2-{[(tert-butoxy)carbonyl]amino}acetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The title compound was prepared according to the procedure as described in Example 17 Step 1 using 2-((tert-butoxycarbonyl)amino)acetic acid (1 g, 5.7 mmol) in DCM (25 mL) and H2O (25 mL), NaHCO3 (1.92 g, 22.8 mmol), TBAHSO4 (194 mg, 0.57 mmol) and a solution of chloromethyl sulfochloridate (693 mL, 6.8 mmol) in DCM (5 mL). The title compound was obtained as colorless oil (911 mg, 71.3%).

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-0088c5696bdd4a198c42c89ac1a3e887
出典データセット
uspto-grants-2016_07
特許番号
US09399639B2

反応ノート

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