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2,6-Di-tert-butyl-4-methylphenol → HCID 178418777、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Di-tert-butyl-4-methylphenol | HCID 31404 | — |
| 反応物 | Tri(butyl)vinyltin | HCID 53438229 | — |
| 反応物 | HCID 178418932 | HCID 178418932 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | HCID 178418777 | HCID 178418777 | — |
反応手順
A solution of Intermediate 121 (500 mg), tri(n-butyl)vinyltin (518 μl, Tokyo Kasei Kogyo), tetrakis(triphenylphosphine)palladium(0) (28.1 mg) and 2,6-di-tert-butyl-p-cresol (3.2 mg, Tokyo Kasei Kogyo) in toluene (10 ml) was stirred at 110° C. for 3 hours. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1) to obtain the title compound (409.5 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094789B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-5bdc0731d83a4375b57f763a35e61dd4 |
| 出典メモ | uspto-grants-2006_08 |