Potassium Carbonate → 1-Butyl-5-ethyluracil

HRID 1057253

反応式

HRID 1057253 の反応式
[CH2:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:2]([N:7]1[CH:8]=[C:3]([CH2:1][CH3:2])[C:4](=[O:10])[NH:5][C:6]1=[O:9])[CH2:1][CH2:3][CH3:8]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 732675-Ethyl-2,4(1H,3H)-pyrimidinedione

生成物 1

HCID 186710321-Butyl-5-ethyluracil収率 69%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

To a solution of 5.6 g (40 mmol) of 5-ethyluracil in 60 ml of dimethylformamide, 5.5 g (40 mmol) of potassium carbonate and 2.3 ml (20 mmol) of n-iodobutane were added and stirred for 2 hours at 120° C. The reaction mixture was concentrated under reduced pressure and distributed between dichloromethane and aqueous solution of ammonium chloride, and the organic layer was concentrated under reduced pressure. The residue was adsorbed on a silica gel column and eluted with 30% ethyl acetate/hexane to obtain 2.7 g of 1-butyl-5-ethyluracil (Yield: 69%).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. concentrationthe organic layer was concentrated under reduced pressure
  3. washeluted with 30% ethyl acetate/hexane

出典と根拠

ORDレコード
ord-536f8196f59441eb9dc123a8eaaba2eb
出典データセット
uspto-grants-2003_02
特許番号
USRE037979E1

関連ノート

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