Morpholine → 7-Methoxy-2-morpholinocarbonylbenzofuran
反応式
[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([C:12]([OH:14])=O)=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[O:14])=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1参加物
3
実験手順
Substantially the same procedure as in Example 219 was repeated using a starting material, 7-methoxybenzofuran-2-carboxylic acid, and morpholine to give 7-methoxy-2-morpholinocarbonylbenzofuran (Compound 329a). Successively, it was formylated to give 4-formyl-7-methoxy-2-morpholinocarbonylbenzofuran (Compound 329b), then compound 329b was reacted with methylamine hydrochloride to give compound 329 as a white solid.
出典と根拠
- ORDレコード
- ord-decdb80365924aabb84ca809d98d6bd2
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06514996B2
反応ノート
読み込み中…