Hydrochloric Acid → 7-Methoxy-1-benzofuran-2-carbaldehyde

HRID 1057934ノート

反応式

HRID 1057934 の反応式
[C:1]([C:3]1[O:4][C:5]2[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=1)#N.CC(C[AlH]CC(C)C)C.C[OH:24].Cl>ClCCl.C1(C)C=CC=CC=1>[CH3:13][O:12][C:11]1[C:5]2[O:4][C:3]([CH:1]=[O:24])=[CH:7][C:6]=2[CH:8]=[CH:9][CH:10]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14487Diisobutylaluminum hydrideHCID 2985567-Methoxybenzofuran-2-carbonitrile

生成物 1

HCID 34573107-Methoxy-1-benzofuran-2-carbaldehyde

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 6344Dichloromethane溶媒

実験手順

2-Cyano-7-methoxybenzofuran (0.736 g) was dissolved in dichloromethane (10 ml), and a 1.02N DIBAL solution (5.4 ml) in toluene was added thereto at −4 to −30° C., followed by stirring for one hour. Methanol and dilute hydrochloric acid were added to the mixture, and the solvent was distilled off. The obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1) to give Compound IIad-a (0.371 g, 50%) as an oily substance.

後処理

  1. customat −4 to −30° C.
  2. distillationthe solvent was distilled off
  3. customThe obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1)
  4. customto give Compound IIad-a (0.371 g, 50%) as an oily substance

出典と根拠

ORDレコード
ord-9e9b1694743a4449b93ddf0f1ade65b4
出典データセット
uspto-grants-2003_02
特許番号
US06514996B2

反応ノート

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