4-Bromothiophene-2-carbaldehyde → 4-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-thiophenecarboxaldehyde

HRID 1057960ノート

反応式

HRID 1057960 の反応式
[CH3:1][C:2]1([CH3:17])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6](B(O)O)[CH:5]=[CH:4][C:3]1=2.Br[C:19]1[CH:20]=[C:21]([CH:24]=[O:25])[S:22][CH:23]=1>>[CH3:1][C:2]1([CH3:17])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:19]3[CH:20]=[C:21]([CH:24]=[O:25])[S:22][CH:23]=3)[CH:5]=[CH:4][C:3]1=2

参加物

3

反応物 2

HCID 877924-Bromothiophene-2-carbaldehydeHCID 10353857(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)boronic acid

生成物 1

HCID 186725074-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-thiophenecarboxaldehyde

実験手順

In a similar manner to Example 3(b), by reaction of 4.3 g (18.7 mmol) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylboronic acid with 2.36 g (12.3 mmol) of 4-bromo-2-thiophenecarboxaldehyde, 2.3 g (63%) of the expected aldehyde derivative are obtained, with a melting point of 84-5° C.

後処理

  1. customare obtained, with a melting point of 84-5° C.

出典と根拠

ORDレコード
ord-bce8344ceb424fd689b8f4b759b2b340
出典データセット
uspto-grants-2003_02
特許番号
US06515021B1

反応ノート

読み込み中…