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(E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]propen-1-ol → (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]acrolein
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]propen-1-ol | HCID 19694368 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]acrolein | HCID 19694378 | 89% |
反応手順
A mixture of (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]propen-1-ol (3.85 g), activated manganese dioxide (8.00 g) and dichloromethane (150 ml ) was stirred at room temperature for 2 hours. After the insoluble portion was filtered off, the filtrate was concentrated to yield crystals of (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]acrolein (3.40 g, 89%), which was then recrystallized from dichloromethane-isopropyl ether to yield colorless prisms having a melting point of 132° to 133° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723479 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-20c9273eacd748b48025e08d9d4eba7a |
| 出典メモ | uspto-grants-1998_03 |