2-Chloropyridine → 2-(N-Methyl-N-(2-pyridyl)amino)ethanol

HRID 1058088ノート

反応式

HRID 1058088 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][NH:9][CH2:10][CH2:11][OH:12]>>[CH3:8][N:9]([CH2:10][CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 79772-ChloropyridineHCID 80162-(Methylamino)ethanol

生成物 1

HCID 7374202-(N-Methyl-N-(2-pyridyl)amino)ethanol

実験手順

The reaction of 2-chloropyridine with 2-(N-methyl amino)ethanol provides 2-(N-methyl-N-(2-pyridyl)amino)ethanol (II), which on coupling reaction with 4-fluorobenzaldehyde (III) in an aprotic polar solvent with an alkali metal hydroxide or an alkali metal alkoxide as base yields 4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzaldehyde (IV) with an 88% yield (Reaction I).

出典と根拠

ORDレコード
ord-e58b72df1612415e90e00bb4f473b1d1
出典データセット
uspto-grants-2003_02
特許番号
US06515132B2

反応ノート

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