Chlorine → 2-methyl-4,5-bis(methylsulfonyl)benzoic Acid

HRID 1058139ノート

反応式

HRID 1058139 の反応式
ClCl.[CH3:3][C:4]1[CH:12]=[C:11](Cl)[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>B(O[O-])=O.[Na+]>[CH3:3][C:4]1[CH:12]=[C:11]([S:14]([CH3:10])(=[O:16])=[O:15])[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参加物

4

反応物 2

HCID 24526ChlorineHCID 108244784-chloro-2-methyl-5-(methylsulfonyl)Benzoic acid

生成物 1

HCID 112663132-methyl-4,5-bis(methylsulfonyl)benzoic Acid

試薬・触媒・溶媒 1

HCID 517072Sodium Perborate溶媒

実験手順

in stage c) the chlorine substituent is converted into a second methylsulfonyl group by reacting 2-methyl-4-chloro-5-methylsulfonylbenzoic acid with sodium methylthiolate and then oxidizing the thioether with an oxidizing agent, in particular sodium perborate, to give the corresponding intermediate 2-methyl-4,5-di(methylsulfonyl)benzoic acid,

出典と根拠

ORDレコード
ord-46f227b4b1ca4b0abdffbf2b3e04ef28
出典データセット
uspto-grants-2003_02
特許番号
US06515143B2

反応ノート

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