Hydrochloride methanol → 4-(1-Amino-5-isoquinolyl)aminopiperidine

HRID 10582ノート

反応式

HRID 10582 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([NH:12][CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.Cl.CO>>[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([NH:12][CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 21893726Hydrochloride methanolHCID 219797874-(1-Amino-5-isoquinolyl)amino-1-(tert-butoxycarbonyl)piperidine

生成物 1

HCID 219798644-(1-Amino-5-isoquinolyl)aminopiperidine収率 71.7%

実験手順

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 133 (199 mg) and 10% hydrogen chloride/methanol solution (3 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (101 mg).

後処理

  1. custom(room temperature, 2 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-6a29741c4a614edab796fa123e380462
出典データセット
uspto-grants-2006_08
特許番号
US07094789B2

反応ノート

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