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2-(2-Bromoethoxy)tetrahydro-2H-pyran → 1-(2-Hydroxyethyl)-4-(4-methyl-5-isoquinolyl)aminopiperidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(2-Bromoethoxy)tetrahydro-2H-pyran | HCID 86621 | — |
| 反応物 | 4-Methyl-N-(piperidin-4-YL)isoquinolin-5-amine hydrochloride | HCID 21979810 | — |
| 生成物 | 1-(2-Hydroxyethyl)-4-(4-methyl-5-isoquinolyl)aminopiperidine hydrochloride | HCID 21979983 | — |
反応手順
According to the method of Example 144, an alkylation reaction with 2-(2-bromoethoxy)tetrahydro-2H-pyran and a deprotection reaction were performed by using the compound of Example 106 to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094789B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-d00bddfa7b8a4ef6b23783ff72234805 |
| 出典メモ | uspto-grants-2006_08 |