Pyridinium chloride → HCID 178450100、化合物

HRID 1059138ノート

反応式

HRID 1059138 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([C:19]3[N:20]=[CH:21][N:22](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:23]=3)([OH:18])[CH:15]([CH3:17])[CH3:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([C:19]3[N:20]=[CH:21][NH:22][CH:23]=3)([OH:18])[CH:15]([CH3:17])[CH3:16])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 10176127Pyridinium chlorideHCID 120433891-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

生成物 1

HCID 178450100HCID 178450100、化合物収率 68.5%

実験手順

By the reaction in the same manner as in Example 4-(iii) using 1-(4′-chloro[1,1′-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (3.00 g) and pyridine hydrochloride (1.04 g), the title compound (1.18 g) was obtained as colorless plate crystals.

後処理

  1. customBy the reaction in the same manner as in Example

出典と根拠

ORDレコード
ord-456960dad873419db8b388dda9d83f0f
出典データセット
uspto-grants-2003_02
特許番号
US06518257B1

反応ノート

読み込み中…