N-(3-bromo-4-methoxyphenyl)acetamide → N-{4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-6-methoxy[1,1'-biphenyl]-3-yl}acetamide

HRID 1059184

反応式

HRID 1059184 の反応式
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Br[C:40]1[CH:41]=[C:42]([NH:48][C:49](=[O:51])[CH3:50])[CH:43]=[CH:44][C:45]=1[O:46][CH3:47]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:44]2[C:45]([O:46][CH3:47])=[CH:40][CH:41]=[C:42]([NH:48][C:49](=[O:51])[CH3:50])[CH:43]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4]

参加物

4

反応物 2

HCID 244158N-(3-bromo-4-methoxyphenyl)acetamideHCID 186685784-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid

生成物 1

HCID 18668531N-{4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-6-methoxy[1,1'-biphenyl]-3-yl}acetamide収率 42.6%

試薬・触媒・溶媒 1

HCID 178418397HCID 178418397、化合物触媒

実験手順

By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (3.21 g), N-(3-bromo-4-methoxyphenyl)acetamide (1.05 g) and tetrakis(triphenylphosphine)palladium(0) (0.16 g), the title compound (1.14 g) was obtained as a colorless amorphous powder.

出典と根拠

ORDレコード
ord-195ce4aa1cbd4e5596293b1aa43c8c56
出典データセット
uspto-grants-2003_02
特許番号
US06518257B1

関連ノート

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