Hydrochloric Acid → HCID 178485317、化合物

HRID 1059212ノート

反応式

HRID 1059212 の反応式
[OH:1][CH:2]([C:28]1[CH:33]=[CH:32][C:31]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([NH:42][CH3:43])=[O:41])[CH:35]=2)=[CH:30][CH:29]=1)[CH2:3][C:4]1[N:5]=[CH:6][N:7](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:8]=1.Cl>[C].[Pd]>[OH:1][CH:2]([C:28]1[CH:29]=[CH:30][C:31]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([NH:42][CH3:43])=[O:41])[CH:35]=2)=[CH:32][CH:33]=1)[CH2:3][C:4]1[N:5]=[CH:6][NH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 695319314'-[1-hydroxy-(1-trityl-1H-imidazol-4-yl)ethyl]-N-methyl[1,1'-biphenyl]-3-carboxamide

生成物 1

HCID 178485317HCID 178485317、化合物収率 47.9%

試薬・触媒・溶媒 1

HCID 178418390HCID 178418390、化合物触媒

実験手順

By the reaction in the same manner as in Example 41-(ii) using [4′-[1-hydroxy-(1-trityl-1H-imidazol-4-yl)ethyl]-N-methyl[1,1′-biphenyl]-3-carboxamide (527 mg), 10% palladium carbon (527 mg) and 1N hydrochloric acid (0.935 ml), the title compound (144 mg) was obtained as colorless powder crystals.

出典と根拠

ORDレコード
ord-319f46fec8ab4db1b148e8c0fb17f152
出典データセット
uspto-grants-2003_02
特許番号
US06518257B1

反応ノート

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