Pyridinium chloride → HCID 178489705、化合物

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:20]3[N:21]=[CH:22][N:23](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:24]=3)([OH:19])[CH:16]([CH3:18])[CH3:17])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.Cl.N1C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[CH:11][C:12]([C:15]([C:20]3[N:21]=[CH:22][NH:23][CH:24]=3)([OH:19])[CH:16]([CH3:18])[CH3:17])=[CH:13][CH:14]=2)[CH:6]=[CH:7][CH:8]=1

参加物

反応物 2

HCID 10176127Pyridinium chloride

HCID 18668662HCID 18668662、化合物

生成物 1

HCID 178489705HCID 178489705、化合物収率 88.1%

実験手順

By the reaction in the same manner as in Example 4-(iii) using 1-(3′-methoxy[1,1′-biphenyl]-4-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (960 mg) and pyridine hydrochloride (354 mg), the colorless amorphous title compound (483 mg) was obtained.

後処理

customBy the reaction in the same manner as in Example

出典と根拠

ORDレコード: ord-226ee2ba880549c68e61e8272ef21829
出典データセット: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06518257B1

反応ノート

読み込み中…