Ammonia → 4-Bromoisoindolin-1-one

HRID 1059263ノート

反応式

HRID 1059263 の反応式
[Br:1][C:2]1[C:3]([CH2:12]Br)=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](OC)=[O:6].[NH3:14]>CO.C1COCC1>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:4]2[C:3]=1[CH2:12][NH:14][C:5]2=[O:6]

参加物

4

反応物 2

HCID 222AmmoniaHCID 21907554Methyl 3-bromo-2-(bromomethyl)benzoate

生成物 1

HCID 219075094-Bromoisoindolin-1-one収率 76%

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

Methyl 3-bromo-2-(bromomethyl)benzoate (1.28 g) was dissolved in a 11% solution of ammonia in methanol-THF mixed solution (3:2, 25 ml) and the mixture was stirred at room temperature for 16 h. The reaction mixture was concentrated and the residue was washed with saturated brine. Recrystallization from ethyl acetate-hexane gave the title compound (671 mg, 76%) as colorless needle crystals.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with saturated brine
  3. customRecrystallization from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-6c3f4318b73d4bcfa5a8561fbb63e195
出典データセット
uspto-grants-2003_02
特許番号
US06518257B1

反応ノート

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