Ammonia → 10H-Pyrazino[2,3-b][1,4]benzothiazine-8-methanol

HRID 1059303ノート

反応式

HRID 1059303 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[S:10][C:11]1[C:16](Cl)=[N:15][CH:14]=[CH:13][N:12]=1)[CH2:5][OH:6].Cl.N>CO>[N:15]1[C:16]2[NH:1][C:2]3[CH:3]=[C:4]([CH2:5][OH:6])[CH:7]=[CH:8][C:9]=3[S:10][C:11]=2[N:12]=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 235641353-Amino-4-[(3-chloropyrazin-2-yl)thio]benzyl alcohol

生成物 1

HCID 1094429210H-Pyrazino[2,3-b][1,4]benzothiazine-8-methanol収率 96.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 1.47 g of 3-amino-4-[(3-chloropyrazin-2-yl)thio]benzyl alcohol were added 20 ml of methanol and 0.45 ml of conc. hydrochloric acid and the resulting mixture was heated under reflux for 30 minutes. Then the reaction mixture was made alkaline by adding ice-water and aqueous ammonia. The precipitate was collected by filtration and dried to thereby give 1.23 g of the title compound as yellow crystals.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. filtrationThe precipitate was collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-b7887816f108477fa3562fcf3a99e0b5
出典データセット
uspto-grants-2003_02
特許番号
US06518423B1

反応ノート

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