Hydrochloric Acid → Methyl 1-benzylpiperidine-4-carboximidate dihydrochloride

HRID 1059348

反応式

HRID 1059348 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:16].[CH3:17][OH:18]>>[ClH:16].[ClH:16].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[NH:15])[O:18][CH3:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 7933831-Benzylpiperidine-4-carbonitrile

生成物 1

HCID 18670137Methyl 1-benzylpiperidine-4-carboximidate dihydrochloride

実験手順

A solution of 20 g of 1-benzylpiperidine-4-carbonitrile in a mixture of dry dichlolomethane (200 ml) with methanol (30 ml) was cooled and saturated with a hydrogen chloride gas while maintaining the reaction system at 0° C. or below. After allowing to stand for 4 hours at 0° C., the solvent was distilled off under reduced pressure at room temperature or below and the residue was diluted with ethyl acetate. The colorless crystals thus obtained were ground, filtered and washed with ethyl acetate to thereby give 23.6 g of the title compound.

後処理

  1. temperaturewhile maintaining the reaction system at 0° C. or below
  2. distillationthe solvent was distilled off under reduced pressure at room temperature or below
  3. additionthe residue was diluted with ethyl acetate
  4. customThe colorless crystals thus obtained
  5. filtrationfiltered
  6. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-b1a50a6a66eb4d06b1dfd02973992f7f
出典データセット
uspto-grants-2003_02
特許番号
US06518423B1

関連ノート

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