Ethyl 4-(piperidin-4-yl)-2-methylbutanoate → Ethyl 4-[1-[2-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)ethyl]piperidin-4-yl]-2-methylbutanoate

HRID 1059368ノート

反応式

HRID 1059368 の反応式
CS(O[CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]2[S:16][C:15]3[N:17]=[CH:18][CH:19]=[N:20][C:14]=3[N:13](COC)[C:12]=2[CH:24]=1)(=O)=O.[NH:25]1[CH2:30][CH2:29][CH:28]([CH2:31][CH2:32][CH:33]([CH3:39])[C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:27][CH2:26]1.CC(CC)C([O-])=O>>[N:20]1[C:14]2[NH:13][C:12]3[CH:24]=[C:8]([CH2:7][CH2:6][N:25]4[CH2:30][CH2:29][CH:28]([CH2:31][CH2:32][CH:33]([CH3:39])[C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:27][CH2:26]4)[CH:9]=[CH:10][C:11]=3[S:16][C:15]=2[N:17]=[CH:18][CH:19]=1

参加物

4

反応物 3

HCID 11298836Ethyl 4-(piperidin-4-yl)-2-methylbutanoateHCID 186705792-[10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl]ethyl methanesulfonateHCID 222532972-Methylbutyrate

生成物 1

HCID 11476192Ethyl 4-[1-[2-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)ethyl]piperidin-4-yl]-2-methylbutanoate

実験手順

Starting with 2-[10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl]ethyl methanesulfonate and ethyl 4-(piperidin-4-yl)-2-methylbutanoate, ethyl 4-[1-[2-10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-ethyl]piperidin-4-yl]-2-methylbutanoate was obtained by the same method as the one of Example 63. Next, this product was treated by the same method as the one of Example 8 to thereby give the title compound.

後処理

  1. customwas obtained by the same method as the one of Example 63
  2. additionNext, this product was treated by the same method as the one of Example 8

出典と根拠

ORDレコード
ord-424e495ea4874f809cd54e17529a9b86
出典データセット
uspto-grants-2003_02
特許番号
US06518423B1

反応ノート

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