Potassium Hydroxide → 2-(Pyridin-2-ylmethyl)imidazole

HRID 1059390ノート

反応式

HRID 1059390 の反応式
CN(C)S([N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)(=O)=O.[OH-].[K+]>C(O)C>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][C:7]1[NH:8][CH:9]=[CH:10][N:6]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 18670131HCID 18670131、化合物

生成物 1

HCID 186704242-(Pyridin-2-ylmethyl)imidazole収率 42.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 0.21 g of N,N-dimethyl[2-(pyridin-2-ylmethyl)imidazol-1-yl]sulfonamide in ethanol (2 ml) was added a 2% aqueous solution (20 ml) of potassium hydroxide and the resulting mixture was heated under reflux for 11 hours. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol) to thereby give 0.053 g of the title compound as a colorless oily substance.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 11 hours
  3. distillationAfter distilling off the solvent under reduced pressure
  4. customthe residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol)

出典と根拠

ORDレコード
ord-ef9312a1c2ec499bbd6e8cedad8f66e4
出典データセット
uspto-grants-2003_02
特許番号
US06518423B1

反応ノート

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