3-Bromoaniline → 7-Amino-4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidine

HRID 1059586ノート

反応式

HRID 1059586 の反応式
[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](SC)=[N:7][CH:6]=[N:5][C:4]=2[CH:3]=1.[Br:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18]>>[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8]([NH:18][C:17]3[CH:19]=[CH:20][CH:21]=[C:15]([Br:14])[CH:16]=3)=[N:7][CH:6]=[N:5][C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 115623-BromoanilineHCID 104425627-Amino-4-methylthiopyrido[4,3-d]pyrimidine

生成物 1

HCID 3820597-Amino-4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidine

反応条件

温度
190 °C

実験手順

A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (167 mg, 0.87 mmol) (described in a previous experimental) and 3-bromoaniline (0.75 mL, 7.8 mmol) is stirred under N2 at 190° C. for 2.5 h, and the precipitate which appears on cooling is recrystallized from PriOH. 1H NMR (DMSO) δ 9.91 (1H, brs), 9.34 (1H, s), 8.45 (1H, s), 8.19 (1H, s), 7.84 (1H, d, J=8.0 Hz), 7.34 (1H, t, J=8.0 Hz), 7.29 (1H, d, J=8.2 Hz), 6.68 (2H, brs), 6.45 (1H, s).

後処理

  1. temperatureon cooling
  2. customis recrystallized from PriOH

出典と根拠

ORDレコード
ord-7a605d0fb7ca4c7bba9d893c2e96c9e8
出典データセット
uspto-grants-2003_02
特許番号
US06521620B1

反応ノート

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