Benzylamine → N-[4-(benzylamino)pyrido[4,3-d]pyrimidin-7-yl]acetamide
反応式
[C:1]([NH:4][C:5]1[N:14]=[CH:13][C:12]2[C:11](SC)=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1)(=[O:3])[CH3:2].[CH2:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:1]([NH:4][C:5]1[N:14]=[CH:13][C:12]2[C:11]([NH:24][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1)(=[O:3])[CH3:2]参加物
3
反応条件
- 温度
- 140 °C
実験手順
A mixture of 7-acetylamino-4-methylthiopyrido[4,3-d]pyrimidine (0.40 g, 1.71 mmol) and benzylamine (1.0 mL, 9.15 mmol) is stirred under N2 at 140° C. for 1 h, and the resulting product is chromatographed on silica gel (EtOAc) to give 7-acetylamino-4-benzylaminopyrido[4,3-d]pyrimidine (0.31 g, 62%) as a white solid. 1H NMR (DMSO) δ 10.79 (1H, s), 9.42 (1H, s), 9.23 (1H, t, J=5.8 Hz), 8.49 (1H, s), 8.18 (1H, s), 7.39 (1H, dt, Jd=6.9 Hz, Jt=1.7 Hz), 7.34 (1H, tt, J=7.3, 1.7 Hz), 7.25 (1H, tt, J=7.1, 1.7 Hz), 4.80 (2H, d, J=5.8 Hz), 2.15 (3H, s).