Ammonia → 6-Amino-2-fluoronicotinamide

HRID 1059628ノート

反応式

HRID 1059628 の反応式
[F:1][C:2]1[N:10]=[C:9](F)[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[NH3:12].O>C(N)=O>[NH2:12][C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([F:1])[N:10]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 962WaterHCID 105830482,6-Difluoropyridine-3-carboxamide

生成物 1

HCID 105348946-Amino-2-fluoronicotinamide収率 31%

試薬・触媒・溶媒 1

HCID 713Formamide溶媒

実験手順

A solution of 2,6-difluoronicotinamide (4.68 g, 0.029 mmol) in dry formamide (30 mL) is saturated with ammonia and allowed to stand at room temperature for 24 h. Water (50 mL) is added and the resultant precipitate is filtered off and washed well with water, to give 6-amino-2-fluoronicotinamide (1.41 g, 31%) mp 236-237° C. 1H NMR (DMSO) δ 7.89 (1H, dd, J=10.4, 8.4 Hz), 7.31, 7.16 (1H, 1H, 2 brs,), 6.93 (2H, brs), 6.36 (1H, dd, J=8.4, 2.4 Hz).

後処理

  1. filtrationthe resultant precipitate is filtered off
  2. washwashed well with water

出典と根拠

ORDレコード
ord-8cc5c147cf8d4fbdbaf21d64a3c746ef
出典データセット
uspto-grants-2003_02
特許番号
US06521620B1

反応ノート

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