Water → HCID 22175090、化合物

HRID 1059656ノート

反応式

HRID 1059656 の反応式
[O-:1][CH2:2][CH3:3].[Na+].F[C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[O:12][CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18].O>C(O)C>[CH2:2]([O:1][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[O:12][CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH3:3]

参加物

5

反応物 3

HCID 962WaterHCID 2723922Sodium ethoxideHCID 22175082HCID 22175082、化合物

生成物 1

HCID 22175090HCID 22175090、化合物収率 50.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of sodium ethoxide (0.9 g, 13 mmol) in ethanol (10 mL) was added all at once 10 (1.07 g, 4.4 mmol). The resulting mixture was stirred at room temperature for 48 hours, then poured into water (100 mL). The resulting mixture was extracted with ether (3×50 mL). The ether extracts were combined, dried (MgSO4) and concentrated. The resulting amber oil was chromatographed (silica gel, hexane-acetone, 4:1) to give 11 as a yellow oil (0.6 g).

後処理

  1. extractionThe resulting mixture was extracted with ether (3×50 mL)
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated
  4. customThe resulting amber oil was chromatographed (silica gel, hexane-acetone, 4:1)

出典と根拠

ORDレコード
ord-9bba8a0f8cfe460c9c449ea59c74940d
出典データセット
uspto-grants-2003_02
特許番号
US06521622B1

反応ノート

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