3-Amino-1-propanol → N-(3-Hydroxypropyl)trifluoroacetamide
反応式
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[F:6][C:7]([F:13])([F:12])[C:8](OC)=[O:9]>CO>[F:6][C:7]([F:13])([F:12])[C:8]([NH:1][CH2:2][CH2:3][CH2:4][OH:5])=[O:9]参加物
4
実験手順
3-Amino-1-propanol (10.0 mL, 0.131 mol) and methyl trifluoroacetate (65 mL, 0.646 mol) in methanol (200 mL) were refluxed for 1.5 h, cooled and concentrated to give 2,2,2-trifluoro-N-(3-hydroxypropyl)-acetamide (22.87 g, quantitative) as a light yellow oil which was used without purification. NMR CDCl3 δ 7.45 (br s, 1H), 3.77 (t, J=5.5 Hz, 2H), 3.53-3.42 (m, 2H), 2.45 (s, 1H), 1.83-1.75 (m, 2H).
後処理
- temperaturecooled
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-d7a3f12b09aa4c7b886399a8271df82c
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06521630B1
反応ノート
読み込み中…