Potassium Bromide → HCID 12044122、化合物

HRID 1059697ノート

反応式

HRID 1059697 の反応式
[NH2:1][C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH2:22][CH2:23][N:24]([CH2:27][CH2:28][CH2:29][NH2:30])[CH2:25][CH:26]=2)=[CH:17][CH:16]=1.CC1C=CC=C2C=1N[C:39](=[O:42])NC2=O.[K+].[Br-]>>[Cl:13][C:10]1[C:11]([CH3:12])=[C:2]2[C:3]([C:4](=[O:6])[N:30]([CH2:29][CH2:28][CH2:27][N:24]3[CH2:23][CH:22]=[C:21]([C:18]4[CH:19]=[CH:20][C:15]([Cl:14])=[CH:16][CH:17]=4)[CH2:26][CH2:25]3)[C:39](=[O:42])[NH:1]2)=[CH:8][CH:9]=1

参加物

5

反応物 4

HCID 253877Potassium BromideHCID 3340238-Methylquinazoline-2,4(1H,3H)-dioneHCID 11276773HCID 11276773、化合物HCID 14155405Benzoic acid, 2-amino-4-chloro-3-methyl-, methyl ester

生成物 1

HCID 12044122HCID 12044122、化合物

実験手順

The same general procedure was followed as in Example 7 with starting materials, 2-amino-3-methyl-4-chloro-benzoic acid, methyl ester and 3-[4-(4-Chloro-phenyl)-3,6-dihyro-2H-pyridin-1-yl]-propylamine to yield 7-Chloro-3-{3-[4-(4-chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl{-8-methyl-1H-quinazoline-2,4-dione. The maleate salt of the compound has the following was found to have: Mp. 208-210° C.; 1H NMR DMSO-d6 δ 10.90 (s, 1H), 9.44 (brd s, 1H), 7.80 (d, J=8.7 Hz, 1H), 7.46 (dd, J=8.7, 20.5 Hz, 4H) 7.28 (d, J=8.5 Hz, 1H), 6.20 (brd s, 1H), 6.00 (s, 2H), 3.98 (t, J=6.4 Hz, 2H), 3.84-3.54 (m, 2H), 3.38-3.26 (m, 2H), 3.25-3.10 (m, 2H), 2.75-2.624(m, 2H), 2.39 (s, 3H), 2.10-1.99 (m, 2H); IR (KBr) 3351, 3226, 3071 2965, 2728, 2603, 1904, 1714, 1656, 1612, 1596, 1448, 1353, 1321, 1294, 1261, 1205, 1152, 1134, 1094, 1011, 989, 950, 922, 866, 836, 811, 763, 729, 706, 682, 645, 579, 523, 511, 499, 468, 441, 404; Analysis calculated for C23H23Cl2N3O2.C4H4O4: C, 57.86; H, 4.86; N, 7.50. Found: C, 57.55; H, 4.79; N, 67.36.

後処理

  1. customto yield 7-Chloro-3-{3-[4-(4-chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl

出典と根拠

ORDレコード
ord-3898672e0ac74f719ffe7385d790e249
出典データセット
uspto-grants-2003_02
特許番号
US06521630B1

反応ノート

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