Hydrochloric Acid → (5-(1-Hydroxy-1-methyl-ethyl))-pyridine-2-sulfonic acid amide

関与物質

反応手順

To a solution of 5-isopropyl-pyridine-2-sulfonamide potassium salt (synthesis described in EP 799 209) in water (10 ml) were added 1.2 g of KMnO4 at RT and the mixture was then refluxed for 30 minutes. The mixture was cooled to RT, acidified with diluted HCl and the product was extracted into AcOEt. The organic layer was washed with water, dried over Na2SO4 and concentrated in vacuo to give (5-(1-hydroxy-1-methyl-ethyl))-pyridine-2-sulfonic acid amide as yellow oil. El mass spectrum, m/e 216 (M calculated for: C8H12N2O3S 216).

情報源と証拠