Hydrochloric Acid → N-[(5-isoquinolyl)sulfonyl]-2,2-dimethyl-1,3-propylenediamine

反応式

C(OC([NH:8][CH2:9][C:10]([CH3:27])([CH3:26])[CH2:11][NH:12][S:13]([C:16]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:17]=1[CH:18]=[CH:19][N:20]=[CH:21]2)(=[O:15])=[O:14])=O)(C)(C)C.Cl>CO>[CH:21]1[C:22]2[C:17](=[C:16]([S:13]([NH:12][CH2:11][C:10]([CH3:27])([CH3:26])[CH2:9][NH2:8])(=[O:14])=[O:15])[CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:19][N:20]=1

参加物

実験手順

According to Reference Example 5, Step C, a reaction was performed by using Intermediate 57 (11 g) and 10% hydrogen chloride in methanol (80 ml) to obtain the title compound (7.58 g).

出典と根拠

ORDレコード: ord-9bdeb39ac076409d9aa1b08b86692b72
出典データセット: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07094789B2

反応ノート

読み込み中…

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 21979795N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-2,2-dimethyl-1,3-propylenediamine

生成物 1

HCID 21979981N-[(5-isoquinolyl)sulfonyl]-2,2-dimethyl-1,3-propylenediamine収率 92.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

According to Reference Example 5, Step C, a reaction was performed by using Intermediate 57 (11 g) and 10% hydrogen chloride in methanol (80 ml) to obtain the title compound (7.58 g).

出典と根拠

ORDレコード: ord-9bdeb39ac076409d9aa1b08b86692b72
出典データセット: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07094789B2

反応ノート

読み込み中…