Hydrochloric Acid → HCID 178466935、化合物

HRID 1059935ノート

反応式

HRID 1059935 の反応式
C(OC([NH:8][C:9]([NH:26]C(OC(C)(C)C)=O)=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH:22]=[C:21]([O:23][CH2:24][CH3:25])[CH:20]=[CH:19][N:18]=2)[CH:12]=1)=O)(C)(C)C.[ClH:34]>ClCCl.O1CCOCC1>[ClH:34].[ClH:34].[CH2:24]([O:23][C:21]1[CH:20]=[CH:19][N:18]=[C:17]([C:13]2[CH:12]=[C:11]([NH:10][C:9]([NH2:26])=[NH:8])[CH:16]=[CH:15][CH:14]=2)[CH:22]=1)[CH3:25]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 136134137N,N'-bis(tert-butoxycarbonyl)-N''-(3-(4-ethoxypyridin-2-yl)phenyl)guanidine

生成物 1

HCID 178466935HCID 178466935、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of N,N′-bis (tert-butoxycarbonyl)-N″-(3-(4-ethoxypyridin-2-yl)phenyl)guanidine (200 mg) in dichioromethane (2 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 4 ml), and the mixture was stirred at room temperature for 16 hours. The solvent was evaporated under reduced pressure. To the residue was added 10% ethanol in ethyl acetate (50 ml), and the precipitate was collected by filtration and dried under reduced pressure to give 3-(4-ethoxypyridin-2-yl)phenylguanidine dihydrochloride (126 mg).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 10% ethanol in ethyl acetate (50 ml)
  3. filtrationthe precipitate was collected by filtration
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-59816dafcd0147469b08347bb4cbe2b4
出典データセット
uspto-grants-2003_02
特許番号
US06521643B1

反応ノート

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