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4-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole → Methyl 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)bezofuran-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole | HCID 9794289 | — |
| 反応物 | Methyl 5-hydroxybenzofuran-2-carboxylate | HCID 12208973 | — |
| 生成物 | Methyl 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)bezofuran-2-carboxylate | HCID 70290035 | 87% |
反応手順
In the same manner as in Reference Example 4, methyl 5-hydroxybenzofuran-2-carboxylate was reacted with 4-chloromethyl-5-methyl-2-phenyloxazole to yield methyl 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)bezofuran-2-carboxylate (yield 87%), which was then recrystallized from acetone-ethyl acetate to yield colorless prisms having a melting point of 177° to 178° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723479 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-b3116d4c51654c129518e27f86a5d786 |
| 出典メモ | uspto-grants-1998_03 |