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tert-butyl N-{[4-(aminomethyl)phenyl]methyl}carbamate → N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-1,4-xylylenediamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-butyl N-{[4-(aminomethyl)phenyl]methyl}carbamate | HCID 3354775 | — |
| 反応物 | Isoquinoline-5-sulfonyl chloride hydrochloride | HCID 13116932 | — |
| 生成物 | N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-1,4-xylylenediamine | HCID 69523966 | 82.7% |
反応手順
According to Reference Example 5, Step B, a reaction was performed by using isoquinoline-5-sulfonyl chloride hydrochloride (10 g) and Intermediate 59 (8.96 g) to obtain the title compound (13.39 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094789B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-cc24d669fdfd47959b83d7a2b71561b6 |
| 出典メモ | uspto-grants-2006_08 |