Phosphorus oxychloride → HCID 18667574、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][C:15](=O)[NH:16]3)=[CH:11][CH:10]=2)[CH:4]=1.P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:15]1[CH:14]=[CH:13][C:12]2[C:17](=[CH:18][C:9]([C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][N:6]=3)=[CH:10][CH:11]=2)[N:16]=1参加物
3
実験手順
A suspension of 7-(4-methoxypyridin-2-yl)-2-quinolone (130 mg) in phosphorus oxychloride (5 ml) was refluxed for 2 hours. The mixture was evaporated under reduced pressure. The residue was poured into a saturated aqueous sodium hydrogencarbonate solution and extracted with dichloromethane. The organic layer was washed with brine, dried over sodium sulfate and evaporated under reduced pressure to give 2-chloro-7-(4-methoxypyridin-2-yl)quinoline (140mg).
後処理
- temperaturewas refluxed for 2 hours
- customThe mixture was evaporated under reduced pressure
- additionThe residue was poured into a saturated aqueous sodium hydrogencarbonate solution
- extractionextracted with dichloromethane
- washThe organic layer was washed with brine
- dry with material